Atherogenic index of plasma aip is a logarithmically transformed ratio of molar concentrations of triglycerides to hdlcholesterol. The concept of precision extended to the atherogenic index. Ra causes significant morbidity as a result of synovial inflammation, joint destruction and associated disability. Article as pdf 81 kb article as epub article as epub. Atherogenic index in recent years has started to gain importance as an indicator of atherosclerosis. Inflammatory marker values erythrocyte sedimentation rate esr, creactive pro. In greek, athere means gruel, and skleros means hard.
Besides the attempts to identify new risk factors, the proper management of traditional cv risk factors such as dyslipidemia should become a priority in the periodic evaluation of every ra patient. Diet, atherogenic definition of diet, atherogenic by. The atherogenic index of plasma and the risk of mortality. Atherogenic index of plasma and triglyceridehighdensity. Cardiovascular cv diseases are a serious concern in chronic inflammatory diseases. Diabetic and nondiabetic patients with albuminuria have. Lipid profile and atherogenic indices and their association. Atherogenic index of plasma and risk of cardiovascular.
Atherogenic index of plasma aip is a novel indicator involved in. Atherogenic index as a predictor of atherosclerosis in. Existence of hypertriglyceridemia will increase the activity. The atherogenic index of plasma aip, defined as the base 10 logarithm of the ratio of plasma triglyceride tg to high density lipoprotein cholesterol hdlc, has been employed as a predictor of cardiovascular risk. Mean age of participants was 345 years, mean fasting blood glucose in prediabetes was 1175 mgdl and diabetes was 14919 mgdl. Atherogenic index of plasma aip is the new marker of atherogenicity, aip is the ratio calculated as log tghdlc. Atherogenic definition is relating to or causing atherogenesis.
The atherogenic index lipids in health and disease. Atherosclerosis is a disease in which the inside of an artery narrows due to the buildup of plaque. Fatty acids profile, atherogenic ia and thrombogenic it. Fatty acid and cholesterol profiles, hypocholesterolemic, atherogenic, and thrombogenic indices of broiler meat in the retail market youssef a. Atherogenic index of plasma as useful predictor of. Atherogenic index of plasma aip was found to be one of the strongest markers in predicting the cardiovascular disease cvd risk. Men with a predominance of small, dense ldl pattern b consuming the high fat diet n 18 exhibited a twofold greater reduction in ldl cholesterol than men within pattern a design dreon et al. Atherogenic definition of atherogenic by merriamwebster. Atherogenic index in type 2 diabetes and its relationship with chronic microvascular complications 20,22 the most recent study was a six month prospective trial that investigated the effects of a bergamot extract on cardiometabolic parameters, including plasma lipids, atherogenic lipoproteins and subclinical atherosclerosis. In particular, atherogenic dyslipidemia, which means a concurrence of high triglyceride tg and low highdensity lipoprotein cholesterol hdlc levels, has been shown to be closely associated with adverse clinical outcomes in the general population, as well as high risk. The liver tissues were collected, washed thoroughly in normal saline, bloated and preserved at 40. Atkins diet program rapidly decreases atherogenic index of. This is an open access article distributed under the terms of the creative commons attribution. Atherogenic index of plasma aip is a logarithmically transformed ratio of molar.
Atherogenic index of plasma was calculated as logarithm of tghdlc ratio molar conc and correlated with cvd risk. Atherogenic index as a predictor of cardiovascular risk. We investigated lipid profiles and lipoprotein modification after immunointervention in patients with early rheumatoid arthritis era. Atherogenic index of plasma is related to arterial stiffness. Pdf aipatherogenic index of plasma as a significant. Original article association of uric acid, atherogenic.
The strong correlation of aip with lipoprotein particle size may explain its high predictive value. Atherogenic index and highdensity lipoprotein cholesterol. This study was to determine the aip and its relationship with other cvd risk factors. The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the chinese han population. Atherogenic lipoprotein profile of plasma is an important risk factor for cvd. Atherogenic index of plasma aip is the new marker of atherogenicity, since the aip is related directly to the atherosclerosis risk. These patients had disease durations of less than one year and had not had prior treatment for it. Introduction cardiovascular disease c vd is the cause of one third of deaths worldwide and this statue will progress because of increasing cvds risk factors1.
Symptoms, if they occur, generally do not begin until middle age. Atherogenic definition and meaning collins english. Implications in assessment of cardiovascular disease risk. Use conditional functions if syntax is ifcondition. Pcsk9 regulates the surface expression of ldlrs by targeting for lysosomal degradation brown ms, et al. Atherogenic definition of atherogenic by the free dictionary. In column e, evaluate if a person has high atherogenic risk or not. Atherogenic definition of atherogenic by medical dictionary.
Search for abbreviation meaning, word to abbreviate, or lists of abbreviations. Understanding the relationship between atherogenic index of plasma and cardiovascular disease risk factors among staff of an university in malaysia. Broiler meat is an essential source of food due to its favourable effects on human health derived. Fiftyeight patients with era who met the american college of rheumatology acr criteria were included in the study. We use cookies to help provide and enhance our service and tailor content and ads. Atherogenic index and highdensity lipoprotein cholesterol as. Epidemiological studies have shown an increased premature mortality in patients with ra compared with the general population 37. Atherogenic lipoproteins and cardiovascular disease. Atherogenic definition and meaning collins english dictionary. The atherogenic index of plasma and the risk of mortality in. Cholesterol and saturated fat are not the enemy by chris kresser on april 19. Cardiovascular cv diseases are a serious concern in rheumatoid arthritis ra, accounting for approximately onethird to onehalf of all rarelated deaths. The atherogenic coefficient is used in diagnostics most often when precise determination of the state of fat metabolism is required. Evaluating the utility of plasma atherogenic index among.
Atherogenic index all you need to know about this heart. As atherogenic index of plasma aip is a strong marker to predict the risk of atherosclerosis and coronary heart disease, we assessed the correlation between aip and other important factors. The atherogenic index of plasma aip is a critical index that can be used as a standalone index for cardiac risk estimation 8. Atherogenic index has been suggested to be less susceptible to disease activity variation during large periods of time. Calculate atherogenic index of plasma in the column d. Original article association of uric acid, atherogenic index. This study determined the effect of the initial phase of atkins diet program, consisting in 20. Original article effects of antioxidant vitamins along with. It is characterized by high ratio of ldlc to hdlc 8. Comparative study for atherogenic index of plasmaaip. A marker of cardiovascular disease article pdf available in medical journal of the islamic republic of iran 291.
This was a crosssectional study conducted among 108 postmenopausal. A comparison of atherogenic indices among untreated. Patil 2, shrilaxmi bagali 3, anita deshpande 4, gouhar banu shaikh 5, manjunatha aithala 6 1 lecturer, dept of physiology, b. Atherogenic lipid profile is a feature characteristic of. Few studies has investigated the interrelationship between atherogenic index of plasma aip and coronary heart disease chd especially in asians. This crosssectional study was done among 349 staff of a public university in sarawak. Fatty acid and cholesterol profiles, hypocholesterolemic. Under favorable conditions, bad cholesterol goes into a bound state, that is, turns into lowdensity lipoproteins. Tyagi3 1 department of biochemistry, lady hardinge medical college. Atherogenic lipoprotein phenotype and dietgene interactions. Cvd risk than are other atherogenic indices4 or individual lipoproteins.
Pdf aipatherogenic index of plasma as a significant predictor of. Definition, atherogenic diet and measurement of the atherogenic index by dr. The atherogenic diet, described by kramsch and hollander 5, and the drugweregiven daily, 7 da weekfor 24 wk. Rheumatoid arthritis ra is a chronic systemic disease affecting primarily the synovium, leading to joint damage and bone destruction. This crosssectional study was a part of national noncommunicable risk factors surveil lance system data that has been established since 2004.
Introduction cardiovascular disease c vd is the cause of one third of deaths worldwide and this statue will progress because of increasing cvds risk factors 1. The atherogenic index offers a picture of your lipid profile and when assessed with other metabolic and medical conditions can be a valid predictor of heart disease. Atherosclerosis definition atherosclerosis is the build up of a waxy plaque on the inside of blood vessels. Ath erogenic index of plasma aip is calculated as log tghdlc and it has been designated as a predictor of atherosclerosis 8, 9 and surrogate of small lowdensity lipoprotein particle size 79. May 15, 20 as all potentially atherogenic lipoprotein particles contain only one molecule of apob and various amounts of cholesterol, the concentration of apob is a better marker of atherogenic particle numbers than ldlc and nonhdlc. Atherogenic index of plasma aip, defined as the logarithm of triglycerides to highdensity lipoprotein cholesterol. Cameron troup md in hematological diseases atherogenesis is the formation of plaque in the inner lining of the arteries and is associated with coronary heart disease or coronary heart disease. Atherosclerosis, a progressive process responsible for most heart disease, is a type of arteriosclerosis or hardening of the arteries. Subjects were categorized on the basis of ldl subclass patterns during consumption of the high fat diet, i. As atherogenic index of plasma aip is a strong marker to predict the risk of atherosclerosis and coronary heart disease, we assessed the corre lation between aip and other important factors. Understanding the relationship between atherogenic index. Antiatherogenic medical definition merriamwebster medical. The liver homogenates were prepared in trishydrochloride buffer. Pdf various indices have been used for the diagnosis and prognosis of cardiovascular disease cvd.
There was significant lipidperoxidation in hyperlipidemic. Arteriosclerosis from the greek arteria, meaning artery is a general term for hardening of the arteries. The concept of precision extended to the atherogenic index of. Home june 2011 volume 29 issue the atherogenic index of plasma can easily identify an incre. The lay press has again questioned the role of cholesterol in the pathophysiology of atherosclerotic cardiovascular disease and the relative benefit of statin therapy especially in healthy people with no heart disease.
The other group of five monkeys mean body weight 6. Sep 15, 2017 medicine that initiates or accelerates atherogenesis. Atherogenic index of plasma predicts uric acid in diabetes 5738 int j clin exp med 2014. Original article effects of antioxidant vitamins along. Understanding the relationship between atherogenic index of.
What is an atherogenic diet an atherogenic diet is one that promotes atheromas, which are inflamed plaques on the insides of arteries. Nov 14, 2019 pathology the formation of atheromas, especially on the walls of the arteries. Effect of one week treatment with fenugreek ethanol extract fe at a dose of 250 mgkg and catechu ethyl acetate extract ce at a dose 500 mgkg and its low dose combination 150. Ldlc most underestimates the risk in subjects with an increased number of cholesteroldepleted small dense ldl. We seek to quantify the analytical precision of the aip using the coefficients of variation cvs of the tg and hdlc assays. Pdf dyslipidemia is one of the most important factors for coronary artery disease cad.
The atherogenic coefficient ca is calculated using certain cholesterol fractions. In the united states the life time risk for incidence of. The atherogenic index of plasma is a strong and independent. Atherogenic index as a predictor of cardiovascular risk among women with different grades of obesity pallavi s. Atheromas are the hallmark of a cardiovascular disease called atherosclerosis a primary risk factor for heart attack and stroke. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are affected. The paucity of data regarding the relationship between atherogenic index of plasma aip and risk of cardiovascular disease cvd in postmenopausal women living in subsaharan africa prompted us to conduct this study which aimed at assessing the interplay between aip and risk of cvd among cameroonian postmenopausal women. The atherogenic index of plasma aip, a new comprehensive. Cardiovascular risk factors and atherogenic indices in an iranian. The atherogenic index of plasma which is a mathematical relationship between tg and hdlc has been successfully used as an additional index when assessing cardiovascular cv risk factors 15, 16. Pdf the atherogenic index of plasma is a strong and independent. A total of 63 fmf patients and 51 healthy individuals were included in this retrospective study. Formation of atheromatous deposits, especially on the innermost layer of arterial walls. Atherogenic index, cardiovascular disease, lipid profile, coronary.